On Windows Vista / Windows 7 / Windows 8, you need to run the immunization with elevated privileges, otherwise all global immunizations will fail.
To elevate, right-click the Spybot – Search & Destroy shortcut and choose Run as Administrator.
Spybot 2 will offer you to run the Immunization elevated if you do not run it as described above.
If you have chosen to not have this dialog shown again when it was previously shown,
you can re-enable it by using the Dialogs tab of the Settings window.
If you think nothing has been immunized, please make sure you have clicked on “Check system” which can be found on the navigation bar on the left. This will check for already applied immunization.
In order to immunize correctly please close all open browsers.
Also, using more than one security software with resident protection can cause conflicts.