If a spy is removed, the application that has installed it may no longer work . Spybot-S&D is able to replace a few spies with harmless dummies, but sometimes this is not possible. In this case you should either search for a good alternative that comes without spy- or adware, or use the Recovery option in Spybot-S&D to restore the spy.
In the later case, you can do it step by step, until you find the files that are absolutely necessary for the spy. So you can keep at least some files from your system, like the data saved about you