Spybot – Search & Destroy should uninstall from the Windows Add/Remove Software control panel without problems.
If this does not work, you can also run the uninstaller file manually. This file can be found at:
C:\Program Files (x86)\Spybot – Search & Destroy 2\unins000(.exe)
Or on a 32-bit/x86 PC:
C:\Program Files\Spybot – Search & Destroy 2\unins000(.exe)
The following directories will not be removed during the uninstall procedure. if you want these folder to be deleted, you will have to remove them manually.
C:\Documents and Settings\All Users\Application Data\Spybot – Search & Destroy\
Windows Vista or Windows 7 or Windows 8:
C:\ProgramData\Spybot – Search & Destroy
(Please note that the Application Data Folder is hidden. So if you cannot find this folder please check your folder properties.)
Explanation: These folders contain your preferences settings for Spybot, and the backups that Spybot creates when the System Scan is run. When Spybot is uninstalled and removed from your PC, the backups it has created are also removed.
If you are using Windows 10 and Spybot is not working/uninstalling since the upgrade, please see here for a solution to this issue.