There was a bug in one of our latest detections which could cause wrong path references in our software. The update that will fix it is available now (use the integrated update function or this manual update).

This error could occur or could be caused in some media player software, e.g. if you have played/opened a CD or a DVD and then closed the software. Most media software tries to open the most recently played media, which then was the media in the drive. This error could occur in the Windows media player as well. If this error is caused by Spybot-S&D then it will probably be fixed with the latest update.

If this does not help, please have a look at the Microsoft knowledge base.